Synthesis of peptide nucleic acid monomers

L. Kovács, Z. Timár, B. Penke

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The chemical synthesis of peptide nucleic acid (PNA) monomers is described using Fmoc (backbone), anisoyl (cytosine, adenine), 4-tert- butylbenzoyl (cytosine) and isobutyryl/diphenylcarbamoyl (guanine) protecting group combinations. For the guanine monomer the alkylation was realized both in a Mitsunobu [DIAD, triphenylphosphine or (4- dimethylaminophenyl)diphenylphosphine, tert-butyl glycolate] and in a low- temperature, sodium-hydride mediated alkylation (tert-butyl bromoacetate) to give the N9-substituted derivative.

Original languageEnglish
Pages (from-to)727-729
Number of pages3
JournalNucleosides and Nucleotides
Volume18
Issue number4-5
Publication statusPublished - 1999

Fingerprint

Peptide Nucleic Acids
glycolic acid
Cytosine
Alkylation
Guanine
Monomers
Adenine
Derivatives
Temperature
bromoacetate
triphenylphosphine
sodium hydride

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

Cite this

Synthesis of peptide nucleic acid monomers. / Kovács, L.; Timár, Z.; Penke, B.

In: Nucleosides and Nucleotides, Vol. 18, No. 4-5, 1999, p. 727-729.

Research output: Contribution to journalArticle

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