An efficient two steps procedure has been developed for the synthesis of (R)-(+)-2-[4-(6-chloro-2-benzoxazolyloxy)phenoxy]propionamides (8a-f) starting from (R)-(+)-methyl 2-(4-hydroxyphenoxy)-propionate (4). Treatment of R-(+)-2 with the primary amines 5a-f resulted in 9a-f quantitatively instead of a desired amidation [R-(+)-2 → R-(+)-8a-f]. This unexpected transformation was discussed on the basis of QM calculation.
|Number of pages||6|
|Publication status||Published - Jan 1 2002|
ASJC Scopus subject areas
- Organic Chemistry