Synthesis of novel isoxazoline-fused cyclic β-amino esters by regio- and stereo-selective 1,3-dipolar cycloaddition

Melinda Nonn, Loránd Kiss, Enikö Forró, Zoltán Mucsi, Ferenc Fülöp

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Isoxazoline-fused 2-aminocyclopentanecarboxylate derivatives were regio- and stereo-selectively synthesized by nitrile oxide 1,3-dipolar cycloaddition to cis- or trans-ethyl-2-aminocyclopent-3-enecarboxylates. The compounds were prepared in enantiomerically pure form by enzymatic resolution of the racemic bicyclic β-lactam.

Original languageEnglish
Pages (from-to)4079-4085
Number of pages7
JournalTetrahedron
Volume67
Issue number22
DOIs
Publication statusPublished - Jun 3 2011

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this