Synthesis of novel isoxazoline-fused cyclic β-amino esters by regio- and stereo-selective 1,3-dipolar cycloaddition

Melinda Nonn, L. Kiss, E. Forró, Zoltán Mucsi, F. Fülöp

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Isoxazoline-fused 2-aminocyclopentanecarboxylate derivatives were regio- and stereo-selectively synthesized by nitrile oxide 1,3-dipolar cycloaddition to cis- or trans-ethyl-2-aminocyclopent-3-enecarboxylates. The compounds were prepared in enantiomerically pure form by enzymatic resolution of the racemic bicyclic β-lactam.

Original languageEnglish
Pages (from-to)4079-4085
Number of pages7
JournalTetrahedron
Volume67
Issue number22
DOIs
Publication statusPublished - Jun 3 2011

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Lactams
Nitriles
Cycloaddition
Cycloaddition Reaction
Oxides
Esters
Derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis of novel isoxazoline-fused cyclic β-amino esters by regio- and stereo-selective 1,3-dipolar cycloaddition. / Nonn, Melinda; Kiss, L.; Forró, E.; Mucsi, Zoltán; Fülöp, F.

In: Tetrahedron, Vol. 67, No. 22, 03.06.2011, p. 4079-4085.

Research output: Contribution to journalArticle

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