Synthesis of novel HMG‐CoA reductase inhibitors, II. Heterocyclic analogs of mevinolin

L. Novák, Gábor Hornyánszky, János Rohály, P. Kolonits, Csaba Szántay

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The indole (1) and chroman analogs (2) of mevinolin and their 6S diastereomers 15c and 25d were synthesized in several steps starting with methyl (R)‐3‐[(tert‐butyldimethylsilyl)oxy]‐4‐formylbutyrate (12) and 2‐(indol‐3‐yl)ethanol (3) or 6‐methoxychroman‐4‐one (16), respectively. Compounds 1 and 2 inhibited moderately the HMG‐CoA reductase. The diastereomers 15c and 25d were shown to be inactive.

Original languageEnglish
Pages (from-to)1877-1883
Number of pages7
JournalLiebigs Annalen
Volume1995
Issue number10
DOIs
Publication statusPublished - Sep 22 1995

Keywords

  • 3‐Indolylheptanoates and ‐acetates
  • 4‐Chromanylheptanoates and ‐acetates
  • HMG‐CoA reductase inhibitors

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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