The indole (1) and chroman analogs (2) of mevinolin and their 6S diastereomers 15c and 25d were synthesized in several steps starting with methyl (R)‐3‐[(tert‐butyldimethylsilyl)oxy]‐4‐formylbutyrate (12) and 2‐(indol‐3‐yl)ethanol (3) or 6‐methoxychroman‐4‐one (16), respectively. Compounds 1 and 2 inhibited moderately the HMG‐CoA reductase. The diastereomers 15c and 25d were shown to be inactive.
- 3‐Indolylheptanoates and ‐acetates
- 4‐Chromanylheptanoates and ‐acetates
- HMG‐CoA reductase inhibitors
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry