Synthesis of Novel D-Seco-Pregnenes

Research output: Contribution to journalArticle

10 Citations (Scopus)


A new synthetic route was developed for the preparation of trans-3β-hydroxy-16,17-seco-pregna-5,17(20)-dien-16-al, using Grob fragmentation as the key step. This seco-steroid contains a formyl group and an unsaturated side-chain in a sterically favourable position, and is therefore a promising starting material for the synthesis of novel condensed steroid heterocycles.

Original languageEnglish
Pages (from-to)1387-1393
Number of pages7
JournalMonatshefte fur Chemie
Issue number10
Publication statusPublished - Oct 1 2003


  • D-seco-pregnenes
  • Epoxidations
  • Grob fragmentation
  • Reductions
  • Steroids

ASJC Scopus subject areas

  • Chemistry(all)

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