A new synthetic route was developed for the preparation of trans-3β-hydroxy-16,17-seco-pregna-5,17(20)-dien-16-al, using Grob fragmentation as the key step. This seco-steroid contains a formyl group and an unsaturated side-chain in a sterically favourable position, and is therefore a promising starting material for the synthesis of novel condensed steroid heterocycles.
|Number of pages||7|
|Journal||Monatshefte fur Chemie|
|Publication status||Published - Oct 1 2003|
- Grob fragmentation
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