Synthesis of novel C-2- or C-15-labeled BODIPY—estrone conjugates

Ildikó Bacsa, Csilla Konc, Anna Boglárka Orosz, Gábor Kecskeméti, Réka Rigó, Csilla zvegy-Laczka, E. Mernyák

Research output: Contribution to journalArticle

Abstract

Novel BODIPY–estrone conjugates were synthesized via Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC). Estrone-alkynes or an estrone-azide as starting compounds were synthesized via Michael addition or Sonogashira reaction as key steps. Fluorescent dyes based on BODIPY-core were provided by azide or alkyne functional groups. Fluorescent labeling of estrone was efficiently achieved at the C-2 or C-15 position. The newly-elaborated coupling procedures might have a broad applicability in the synthesis of fluorescent-labeled estrone conjugates suitable for biological assays.

Original languageEnglish
Article number821
JournalMolecules
Volume23
Issue number4
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Estrone
alkynes
Alkynes
Azides
cycloaddition
synthesis
marking
dyes
Cycloaddition
Cycloaddition Reaction
Fluorescent Dyes
Biological Assay
Labeling
Functional groups
Assays
C 15

Keywords

  • BODIPY
  • CuAAC
  • Estrone
  • Estrone conjugates
  • Fluorescent labeling

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Bacsa, I., Konc, C., Orosz, A. B., Kecskeméti, G., Rigó, R., zvegy-Laczka, C., & Mernyák, E. (2018). Synthesis of novel C-2- or C-15-labeled BODIPY—estrone conjugates. Molecules, 23(4), [821]. https://doi.org/10.3390/molecules23040821

Synthesis of novel C-2- or C-15-labeled BODIPY—estrone conjugates. / Bacsa, Ildikó; Konc, Csilla; Orosz, Anna Boglárka; Kecskeméti, Gábor; Rigó, Réka; zvegy-Laczka, Csilla; Mernyák, E.

In: Molecules, Vol. 23, No. 4, 821, 01.01.2018.

Research output: Contribution to journalArticle

Bacsa, I, Konc, C, Orosz, AB, Kecskeméti, G, Rigó, R, zvegy-Laczka, C & Mernyák, E 2018, 'Synthesis of novel C-2- or C-15-labeled BODIPY—estrone conjugates', Molecules, vol. 23, no. 4, 821. https://doi.org/10.3390/molecules23040821
Bacsa I, Konc C, Orosz AB, Kecskeméti G, Rigó R, zvegy-Laczka C et al. Synthesis of novel C-2- or C-15-labeled BODIPY—estrone conjugates. Molecules. 2018 Jan 1;23(4). 821. https://doi.org/10.3390/molecules23040821
Bacsa, Ildikó ; Konc, Csilla ; Orosz, Anna Boglárka ; Kecskeméti, Gábor ; Rigó, Réka ; zvegy-Laczka, Csilla ; Mernyák, E. / Synthesis of novel C-2- or C-15-labeled BODIPY—estrone conjugates. In: Molecules. 2018 ; Vol. 23, No. 4.
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