Synthesis of new tetrazolyldienylphenothiazines as potential multidrug resistance inhibitory compounds

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Ring opening of tetrazolopyridinium salts with phenothiazines yielded stable cis-trans tetrazolyldienamines. One of the new derivatives proved to inhibit significantly the multidrug resistant efflux pump mechanism and, thus, these new phenothiazine derivatives are regarded as promising candidates for further drug research in the MDR area.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalArkivoc
Volume2004
Issue number7
Publication statusPublished - Jan 1 2004

Keywords

  • Dienamine
  • Multidrug resistance
  • Phenothiazine
  • Ring opening

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis of new tetrazolyldienylphenothiazines as potential multidrug resistance inhibitory compounds'. Together they form a unique fingerprint.

  • Cite this