Synthesis of new tetrazolyldienylphenothiazines as potential multidrug resistance inhibitory compounds

Ildikó Nagy, Z. Riedl, G. Hajós, András Messmer, N. Gyémánt, J. Molnár

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Ring opening of tetrazolopyridinium salts with phenothiazines yielded stable cis-trans tetrazolyldienamines. One of the new derivatives proved to inhibit significantly the multidrug resistant efflux pump mechanism and, thus, these new phenothiazine derivatives are regarded as promising candidates for further drug research in the MDR area.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalArkivoc
Volume2004
Issue number7
Publication statusPublished - 2004

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Derivatives
Phenothiazines
Salts
Pumps
Pharmaceutical Preparations
phenothiazine

Keywords

  • Dienamine
  • Multidrug resistance
  • Phenothiazine
  • Ring opening

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis of new tetrazolyldienylphenothiazines as potential multidrug resistance inhibitory compounds. / Nagy, Ildikó; Riedl, Z.; Hajós, G.; Messmer, András; Gyémánt, N.; Molnár, J.

In: Arkivoc, Vol. 2004, No. 7, 2004, p. 177-182.

Research output: Contribution to journalArticle

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AU - Gyémánt, N.

AU - Molnár, J.

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