Synthesis of new steroid-β-lactam hybrids via palladium-catalyzed aminocarbonylation

János Balogh, Rita Skoda-Földes, Katarina Vazdar, Ivan Habuš

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Steroid-β-lactam and steroid-β-lactam-ferrocene conjugates were synthesized via palladium-catalyzed carbonylation of steroidal 17-iodo-16-enes in the presence of 3-amino-azetidin-2-ones. β-Lactam derivatives have been used for the first time as nucleophiles in the aminocarbonylation reaction. The products were obtained in good yields and were characterized by 1H and 13C NMR, IR and HRMS.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalJournal of Organometallic Chemistry
Volume703
DOIs
Publication statusPublished - Apr 15 2012

Keywords

  • Alkenyl iodides
  • Aminocarbonylation
  • Hybrids
  • Palladium
  • β-Lactams

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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