Synthesis of new poly(N-vinyl pyrrolidone-co-maleic acid) - Peptide hormone conjugates with anticancer activity

János Pató, Melinda Móra, Imre Mezö, J. Seprődi, Istv́an Teplán, B. Vincze, Adrienn Kálnay, István Pályi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Gonadotropin releasing hormone (GnRH) is a decapeptide regulating the gonadotropin release in organisms. Its analogues inhibit breast, endometrium and prostatic tumor cell proliferation in vitro. Some analogues were conjugated via the lysine side chain to poly(N-vinyl pyrrolidone-co-maleic acid) using biodegradable and non-biodegradable oligopeptide spacers. The conjugates were prepared by acylation of oligopeptide nitrophenyl esters with the polymeric precursor, poly(N-vinyl pyrrolidone-co-maleic anhydride), by reacting the GnRH analogues with the polymeric active ester. In vitro tests of these products exhibited increased effects on MCF-7 and MDA MB-231 breast, Ishikawa endometrium and PC3 prostatic human tumor cells compared with the parent decapeptides.

Original languageEnglish
Pages (from-to)304-314
Number of pages11
JournalJournal of Bioactive and Compatible Polymers
Volume14
Issue number4
Publication statusPublished - Jul 1999

Fingerprint

Oligopeptides
Peptide Hormones
Endometrium
Gonadotropin-Releasing Hormone
Tumors
Esters
Breast
Maleic Anhydrides
Acylation
Acids
Cell proliferation
Maleic anhydride
Gonadotropins
Lysine
Neoplasms
Cells
Cell Proliferation
N-vinyl-2-pyrrolidinone
In Vitro Techniques
maleic acid

Keywords

  • Anticancer
  • Conjugate
  • GnRH
  • Peptide hormone
  • Poly(N-vinyl pyrrolidone-co-maleic acid)
  • Polymeric drug

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Synthesis of new poly(N-vinyl pyrrolidone-co-maleic acid) - Peptide hormone conjugates with anticancer activity. / Pató, János; Móra, Melinda; Mezö, Imre; Seprődi, J.; Teplán, Istv́an; Vincze, B.; Kálnay, Adrienn; Pályi, István.

In: Journal of Bioactive and Compatible Polymers, Vol. 14, No. 4, 07.1999, p. 304-314.

Research output: Contribution to journalArticle

Pató, János ; Móra, Melinda ; Mezö, Imre ; Seprődi, J. ; Teplán, Istv́an ; Vincze, B. ; Kálnay, Adrienn ; Pályi, István. / Synthesis of new poly(N-vinyl pyrrolidone-co-maleic acid) - Peptide hormone conjugates with anticancer activity. In: Journal of Bioactive and Compatible Polymers. 1999 ; Vol. 14, No. 4. pp. 304-314.
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