Synthesis of new paramagnetic fatty acids and lipophilic spin labels

Mária Balog, Christoph Abé, Tamás Kálai, Heinz Jügen Steinhoff, József Jeko, Kálmán Hideg

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Starting from readily available five-membered cyclic nitrones, paramagnetic analogues of palmitic and hexadec-2E-enoic acids are described with a range of pyrrolidine ring orientations. Herein we report the synthesis of 3,4-disubstituted lipophilic pyrroline nitroxides through a palladium-catalyzed cross-coupling reaction. Lipophilic phosphonium salt and SH-specific labels (methanethiosulfonates and isoselenuronium salts) with allylic and propargylic terminal groups are also described.

Original languageEnglish
Pages (from-to)1663-1670
Number of pages8
JournalSynthesis
Issue number11
DOIs
Publication statusPublished - Jun 19 2007

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Keywords

  • Fatty acids
  • Free radicals
  • Grignard reaction
  • Lipids
  • Palladium-catalyzed reactions

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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