Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230

I. F. Pelyvás, Z. G. Tóth, G. Vereb, A. Balla, E. Kovács, A. Gorzsás, F. Sztaricskai, P. Gergely

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Abstract

The synthesis, chemical derivatization, and investigation of the inhibitory properties of novel cyclitol derivatives on the phosphatidylinositol 4-kinase enzymes PI4K55 and PI4K230 involved in the phosphatidylinositol cycle are reported. Some of the prepared cyclitol derivatives (i.e. 9, 11, 12, and 14) proved to be very powerful and specific irreversible inhibitors of PI4K230 at or below a concentration of 1 mM.

Original languageEnglish
Pages (from-to)627-632
Number of pages6
JournalJournal of Medicinal Chemistry
Volume44
Issue number4
DOIs
Publication statusPublished - Feb 15 2001

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ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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