Synthesis of new 2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-1-yloxyl radicals and 2-substituted-2,5,5-trimethylpyrrolidin-1-yloxyl radicals based α-amino acids

Mária Balog, T. Kalai, J. Jekó́, Heinz Jürgen Steinhoff, Martin Engelhard, K. Hideg

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Unnatural paramagnetic α-amino acids with 2,2,5,5-tetramethyl-2,5- dihydro-1H-pyrrol-1-yloxyl-3-yl radical or 2,5,5-trimethylpyrrolidin-1-yloxyl-2- yl radical side-chains, including a lysine mimic azido precursor and their derivatives, are described. The new set of paramagnetic amino acids presented in this work with different (polar, nonpolar, aliphatic, aromatic, etc.) side-chains offers a useful tool for the ESR study of the protein structure and function after incorporation, fulfilling diverse structural requirements.

Original languageEnglish
Pages (from-to)2591-2593
Number of pages3
JournalSynlett
Issue number14
DOIs
Publication statusPublished - Nov 22 2004

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Amino Acids
Lysine
Paramagnetic resonance
Derivatives
Proteins

Keywords

  • Amino acids
  • Azides
  • Free-radicals
  • O'Donnell synthesis
  • Protecting groups

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis of new 2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-1-yloxyl radicals and 2-substituted-2,5,5-trimethylpyrrolidin-1-yloxyl radicals based α-amino acids. / Balog, Mária; Kalai, T.; Jekó́, J.; Steinhoff, Heinz Jürgen; Engelhard, Martin; Hideg, K.

In: Synlett, No. 14, 22.11.2004, p. 2591-2593.

Research output: Contribution to journalArticle

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AU - Kalai, T.

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AU - Steinhoff, Heinz Jürgen

AU - Engelhard, Martin

AU - Hideg, K.

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