Synthesis of n-glycopeptides applying glycoamino acid building blocks with a combined fmoc/boc strategy

Kinga Rákosi, Orsolya Szolomájer-Csikós, László Kalmár, Zoltán Szurmai, János Kerékgyártó, Gábor K. Tóth

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Mono-, di- and trisaccharide representing the reducing terminal of the core structure of N-glycans were incorporated into Leu-Lys-Asn-Gly-Gly-Pro hexapeptide that is a partial structure of the Trp-cage mini-protein by linear assembly. These studies provide evidence that the used combination of Fmoc and Boc strategy and mild conditions result in glycopeptides in high purity and reasonable yield.

Original languageEnglish
Pages (from-to)679-683
Number of pages5
JournalProtein and Peptide Letters
Volume18
Issue number7
DOIs
Publication statusPublished - Jul 1 2011

Keywords

  • Boc deprotection
  • Carbohydrates
  • N-glycopeptides
  • Solid-phase synthesis
  • Tin(IV) chloride

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

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