Synthesis of n-butyl ester and n-butylamide of methyl-phenylphosphinic acid: Two case studies

Nóra Zsuzsa Kiss, Réka Henyecz, Erzsébet Jablonkai, G. Keglevich

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

n-Butyl methyl-phenylphosphinate and methyl-phenylphosphinic n-butylamide were synthesized by different methods: the reaction of methyl-phenylphosphinic chloride with nBuOH or nBuNH2, respectively, the T3P®-promoted derivatization of methyl-phenylphosphinic acid with nBuOH or nBuNH2, the microwave-assisted direct esterification of the model phosphinic acid, and finally the alkylating esterification with n-butyl bromide under phase-transfer-catalytic and microwave-assisted conditions. The different methods, mostly elaborated by us, were compared from practical and environmentally friendly points of view.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalSynthetic Communications
DOIs
Publication statusAccepted/In press - May 20 2016

Keywords

  • Amidation
  • esterification
  • microwave
  • phase transfer catalysis
  • phosphinic acid
  • T3P® reagent

ASJC Scopus subject areas

  • Organic Chemistry

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