Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors

Tony Tite, Loic Tomas, T. Docsa, P. Gergely, José Kovensky, David Gueyrard, Anne Wadouachi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A new C-glucosylated spiro-sulfamide has been prepared and evaluated toward glycogen phosphorylase inhibition. The synthesis was carried out successfully by nucleophilic displacement of 1-O-tosyl or 1-deoxy-1-iodo-α-d-gluco- hept-2-ulopyranose tetra-O-benzylated derivative using aryl amines, followed by the formation of the corresponding cyclic sulfamide.

Original languageEnglish
Pages (from-to)959-961
Number of pages3
JournalTetrahedron Letters
Volume53
Issue number8
DOIs
Publication statusPublished - Feb 22 2012

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Glycogen Phosphorylase
Amines
Derivatives

Keywords

  • Burgess reagent
  • exo-glucal
  • Gluconolactone
  • Spiro-sulfamide

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors. / Tite, Tony; Tomas, Loic; Docsa, T.; Gergely, P.; Kovensky, José; Gueyrard, David; Wadouachi, Anne.

In: Tetrahedron Letters, Vol. 53, No. 8, 22.02.2012, p. 959-961.

Research output: Contribution to journalArticle

Tite, Tony ; Tomas, Loic ; Docsa, T. ; Gergely, P. ; Kovensky, José ; Gueyrard, David ; Wadouachi, Anne. / Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors. In: Tetrahedron Letters. 2012 ; Vol. 53, No. 8. pp. 959-961.
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AU - Gueyrard, David

AU - Wadouachi, Anne

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