Synthesis of long-wavelength chlorins by chemical modification for methyl pyropheophorbide-a and their in vitro cell viabilities

Jin Jun Wang, Jia Zhu Li, Judit Jakus, Young Key Shim

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12 Citations (Scopus)

Abstract

A series of novel chlorophyll-a homologs with long wavelength absorption were synthesized via modification of methyl pyropheophorbide-a used as starting material. For introducing electron-withdrawing group methylenemalononitrile moiety was established on the periphery of modified chlorin by Knoevenagel reaction of malononitrile with formyl group at 3-, 15-position and 13 1-carbonyl group on the exocyclic ring. All of chlorins containing the methylenemalononitrile structure show Qy-absorption at more than 700 nm. Moreover, we have examined a preliminary in vitro photodynamic anticancer effect of these new derivatives on mouse sarcoma S-180 cell line.

Original languageEnglish
Pages (from-to)122-129
Number of pages8
JournalJournal of Porphyrins and Phthalocyanines
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 2012

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Keywords

  • chemical modification
  • chlorin
  • methyl pyropheophorbide-a
  • visible absorption

ASJC Scopus subject areas

  • Chemistry(all)

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