Synthesis of lipophilic 3,4-disubstituted 2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radicals

T. Kalai, N. M. Baracz, G. Jerkovich, O. H. Hankovszky, K. Hideg

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The Grignard reaction of the esters 2a, b with octylmagnesium bromide proceeds through an allylic rearrangement to give the 3-methylene-4-octyl radical 3. Bromination of its O-acetyl derivative 5 gives allylic bromides 6 and 7 as key intermediates toward lipophilic spin labels.

Original languageEnglish
Pages (from-to)1278-1282
Number of pages5
JournalSynthesis
Issue number10
Publication statusPublished - 1995

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Bromides
Labels
Esters
Derivatives
Spin Labels

Keywords

  • allylic rearrangement
  • Grignard reaction
  • oxaoleic acid
  • SH labels
  • spin labelling

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis of lipophilic 3,4-disubstituted 2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radicals. / Kalai, T.; Baracz, N. M.; Jerkovich, G.; Hankovszky, O. H.; Hideg, K.

In: Synthesis, No. 10, 1995, p. 1278-1282.

Research output: Contribution to journalArticle

Kalai, T. ; Baracz, N. M. ; Jerkovich, G. ; Hankovszky, O. H. ; Hideg, K. / Synthesis of lipophilic 3,4-disubstituted 2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxyl radicals. In: Synthesis. 1995 ; No. 10. pp. 1278-1282.
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