Synthesis of isoxazoline-linked chlorins and their in vitro cell viabilities

Jin Jun Wang, Jia Zhu Li, Yun Wei Li, Judit Jakus, Young Key Shim

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A concise synthesis of isoxazoline-linked chlorins is described. This approach is carried out from methyl pyropheophorbide-a as the starting material via 1,3-dipolar cycloaddition of a vinyl group on the periphery with nitrile oxide to give regioselective products with excellent yields. This method represents an extensive and efficient entry into the functionalization of chlorins with a chlorophyll-α skeleton. Moreover, we have examined a preliminary in vitro effect of these new derivatives on mouse sarcoma S-180 cell line in photodynamic therapy.

Original languageEnglish
Pages (from-to)859-865
Number of pages7
JournalJournal of Porphyrins and Phthalocyanines
Volume14
Issue number10
DOIs
Publication statusPublished - Oct 2010

Keywords

  • 1,3-dipolar cycloaddition
  • chlorine
  • isoxazole
  • methyl pyropheophorbide-a
  • mouse sarcoma S-180 cell
  • photodynamic therapy
  • photosensitizer

ASJC Scopus subject areas

  • Chemistry(all)

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