Synthesis of hydroxynaphthyl-substituted -amino acid derivatives via a modified Mannich reaction

Renáta Csütörtöki, I. Szatmári, Attila Mándi, T. Kurtán, F. Fülöp

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

An efficient one-pot synthesis of hydroxynaphthyl-substituted glycine derivatives from 2- or 1-naphthol, glyoxylic acid, and benzyl carbamate via a modified Mannich reaction is described. The enantiomers were successfully separated on analytical and semipreparative HPLC columns. Their absolute configurations were determined by CD analysis supported by TDDFT CD calculations.

Original languageEnglish
Pages (from-to)1940-1944
Number of pages5
JournalSynlett
Issue number13
DOIs
Publication statusPublished - 2011

Fingerprint

Carbamates
Enantiomers
Glycine
Derivatives
Amino Acids
1-naphthol
2-naphthol
glyoxylic acid

Keywords

  • amino acids
  • CD analysis
  • enantioseparation
  • Mannich bases
  • multicomponent reaction

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis of hydroxynaphthyl-substituted -amino acid derivatives via a modified Mannich reaction. / Csütörtöki, Renáta; Szatmári, I.; Mándi, Attila; Kurtán, T.; Fülöp, F.

In: Synlett, No. 13, 2011, p. 1940-1944.

Research output: Contribution to journalArticle

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AU - Fülöp, F.

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