Synthesis of hydroxynaphthyl-substituted -amino acid derivatives via a modified Mannich reaction

Renáta Csütörtöki, István Szatmári, Attila Mándi, Tibor Kurtán, Ferenc Fülöp

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

An efficient one-pot synthesis of hydroxynaphthyl-substituted glycine derivatives from 2- or 1-naphthol, glyoxylic acid, and benzyl carbamate via a modified Mannich reaction is described. The enantiomers were successfully separated on analytical and semipreparative HPLC columns. Their absolute configurations were determined by CD analysis supported by TDDFT CD calculations.

Original languageEnglish
Pages (from-to)1940-1944
Number of pages5
JournalSynlett
Issue number13
DOIs
Publication statusPublished - Jul 18 2011

Keywords

  • CD analysis
  • Mannich bases
  • amino acids
  • enantioseparation
  • multicomponent reaction

ASJC Scopus subject areas

  • Organic Chemistry

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