Synthesis of hydroxymethylenebisphosphonic acid derivatives in different solvents

Dávid Illés Nagy, A. Grün, Sándor Garadnay, István Greiner, G. Keglevich

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

The syntheses of hydroxymethylenebisphosphonic acid derivatives (dronic acid derivatives) starting from the corresponding substituted acetic acids and P-reagents, mainly phosphorus trichloride and phosphorous acid are surveyed according to the solvents applied. The nature of the solvent is a critical point due to the heterogeneity of the reaction mixtures. This review sheds light on the optimum choice and ratio of the P-reactants, and on the optimum conditions.

Original languageEnglish
Article number1046
JournalMolecules
Volume21
Issue number8
DOIs
Publication statusPublished - Aug 1 2016

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Derivatives
acids
Acids
synthesis
Acetates
acetic acid
reagents
phosphorus
critical point
chlorides
phosphorus chloride
phosphonic acid

Keywords

  • Hydroxymethylenebisphosphonic acid (dronic acid) derivatives
  • P-reagents
  • Solvent
  • Synthesis

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis of hydroxymethylenebisphosphonic acid derivatives in different solvents. / Nagy, Dávid Illés; Grün, A.; Garadnay, Sándor; Greiner, István; Keglevich, G.

In: Molecules, Vol. 21, No. 8, 1046, 01.08.2016.

Research output: Contribution to journalReview article

Nagy, Dávid Illés ; Grün, A. ; Garadnay, Sándor ; Greiner, István ; Keglevich, G. / Synthesis of hydroxymethylenebisphosphonic acid derivatives in different solvents. In: Molecules. 2016 ; Vol. 21, No. 8.
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