Synthesis of hydroxymethylenebisphosphonic acid derivatives in different solvents

Dávid Illés Nagy, Alajos Grün, Sándor Garadnay, István Greiner, György Keglevich

Research output: Contribution to journalReview article

11 Citations (Scopus)


The syntheses of hydroxymethylenebisphosphonic acid derivatives (dronic acid derivatives) starting from the corresponding substituted acetic acids and P-reagents, mainly phosphorus trichloride and phosphorous acid are surveyed according to the solvents applied. The nature of the solvent is a critical point due to the heterogeneity of the reaction mixtures. This review sheds light on the optimum choice and ratio of the P-reactants, and on the optimum conditions.

Original languageEnglish
Article number1046
Issue number8
Publication statusPublished - Aug 1 2016


  • Hydroxymethylenebisphosphonic acid (dronic acid) derivatives
  • P-reagents
  • Solvent
  • Synthesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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