Gyulladásgátló hatású hidrazinoalkoholok szintézise

Translated title of the contribution: Synthesis of hydrazino alcohols with anti-inflammatory activity

L. Lázár, Z. Szakonyi, E. Forró, Márta Palkó, Zita Zalán, I. Szatmári, F. Fülöp

Research output: Contribution to journalArticle

Abstract

Two-step transformations (N-nitrosation and subsequent LiAlH4 reduction) of alicyclic or acyclic amines and 1,2-amino alcohols containing a secondary amino group were applied to prepare novel N1-substituted hydrazines and hydrazino alcohols with wide structural diversity. Methods for the synthesis of certain enantiopure hydrazino alcohols were also developed. The prepared compounds specifically inhibited Vascular Adhesion Protein-1 (VAP-1), a human endothelial cell adhesion molecule with a well-documented role in inflammation. VAP-1 is a semicarbazide-sensitive amine oxidase, activity of which has been demonstrated to play a role in VAP-1 induced inflammation. Some of the hydrazino alcohols obtained reduced the clinical symptoms of inflammation in experimental arthritis in rodents and appear to be potential novel anti-inflammatory drugs.

Original languageHungarian
Pages (from-to)11-18
Number of pages8
JournalActa Pharmaceutica Hungarica
Volume74
Issue number1
Publication statusPublished - 2004

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Blood Vessels
Anti-Inflammatory Agents
Alcohols
Inflammation
Hydrazines
Nitrosation
Amino Alcohols
Amine Oxidase (Copper-Containing)
Proteins
Experimental Arthritis
Amines
Rodentia
Pharmaceutical Preparations
human ESAM protein
lithium aluminum hydride

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Gyulladásgátló hatású hidrazinoalkoholok szintézise. / Lázár, L.; Szakonyi, Z.; Forró, E.; Palkó, Márta; Zalán, Zita; Szatmári, I.; Fülöp, F.

In: Acta Pharmaceutica Hungarica, Vol. 74, No. 1, 2004, p. 11-18.

Research output: Contribution to journalArticle

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AU - Szatmári, I.

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