Synthesis of HSV epitope peptides with acid sensitive ASP-PRO bond

G. Mező, Marianna Mák, Sz. Bősze, F. Hudecz

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Peptides from Herpes Simplex virus type I glycoprotein-D, containing the Asp-Pro bond were synthesised by SPPS using benzyl or cyclohexyl (cHex) protection at the Asp/Glu side chains. Increased stability of the cHex group was demonstrated during the treatment with TMSOTf-thioanisole/TFA. This observation was successfully utilised to prepare partly protected 9-mer peptides and their 18-mer derivatives by fragment condensation both in solution and on solid support.

Original languageEnglish
Pages (from-to)369-376
Number of pages8
JournalProtein and Peptide Letters
Volume3
Issue number6
Publication statusPublished - 1996

Fingerprint

aspartyl-proline
Epitopes
Peptides
Acids
Simplexvirus
Viperidae
Viruses
Condensation
Glycoproteins
Derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Synthesis of HSV epitope peptides with acid sensitive ASP-PRO bond. / Mező, G.; Mák, Marianna; Bősze, Sz.; Hudecz, F.

In: Protein and Peptide Letters, Vol. 3, No. 6, 1996, p. 369-376.

Research output: Contribution to journalArticle

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