Synthesis of highly functionalized fluorinated cispentacin derivatives

Melinda Nonn, Loránd Kiss, Mikko M. Hänninen, Reijo Sillanpää, Ferenc Fülöp

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Fluorinated highly functionalized cispentacin derivatives were synthetised starting from an unsaturated bicyclic β-lactam through C=C bond functionalization via the dipolar cycloaddition of a nitrile oxide, isoxazoline opening, and fluorination by OH/F exchange.

Original languageEnglish
Pages (from-to)2571-2581
Number of pages11
JournalChemistry and Biodiversity
Volume9
Issue number11
DOIs
Publication statusPublished - Nov 1 2012

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Keywords

  • Antibiotics
  • Cispentacin
  • Cycloadditions
  • Fluorination
  • Fluorine compounds
  • Peramivir

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

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