Synthesis of high specific activity [15,16-3H2]buprenorphine

F. Ötvös, S. Hosztafi, C. Simon, G. Toth

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Tritium labelling of buprenorphine, a mixed agonist-antagonist opioid ligand, was performed with a specific activity of 2.35 TBq/mmol (63.6 Ci/mmol) starting with 15,16-didehydrobuprenorphine. Labels at positions 15 and 16 of the morphine skeleton proved to be sufficiently stable under strong acidic or basic conditions.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume36
Issue number1
DOIs
Publication statusPublished - 1995

Fingerprint

Buprenorphine
Tritium
Skeleton
Labeling
Morphine
Opioid Analgesics
Labels
Ligands

Keywords

  • 15,16-Didehydrobuprenorphine
  • Buprenorphine
  • Opioid ligand
  • Tritiation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Clinical Biochemistry
  • Molecular Medicine
  • Pharmacology

Cite this

Synthesis of high specific activity [15,16-3H2]buprenorphine. / Ötvös, F.; Hosztafi, S.; Simon, C.; Toth, G.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 36, No. 1, 1995, p. 79-83.

Research output: Contribution to journalArticle

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