Abstract
Tritium labelling of buprenorphine, a mixed agonist-antagonist opioid ligand, was performed with a specific activity of 2.35 TBq/mmol (63.6 Ci/mmol) starting with 15,16-didehydrobuprenorphine. Labels at positions 15 and 16 of the morphine skeleton proved to be sufficiently stable under strong acidic or basic conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 79-83 |
| Number of pages | 5 |
| Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1995 |
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Keywords
- 15,16-Didehydrobuprenorphine
- Buprenorphine
- Opioid ligand
- Tritiation
ASJC Scopus subject areas
- Analytical Chemistry
- Drug Discovery
- Organic Chemistry
- Clinical Biochemistry
- Molecular Medicine
- Pharmacology
Cite this
Synthesis of high specific activity [15,16-3H2]buprenorphine. / Ötvös, F.; Hosztafi, S.; Simon, C.; Toth, G.
In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 36, No. 1, 1995, p. 79-83.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis of high specific activity [15,16-3H2]buprenorphine
AU - Ötvös, F.
AU - Hosztafi, S.
AU - Simon, C.
AU - Toth, G.
PY - 1995
Y1 - 1995
N2 - Tritium labelling of buprenorphine, a mixed agonist-antagonist opioid ligand, was performed with a specific activity of 2.35 TBq/mmol (63.6 Ci/mmol) starting with 15,16-didehydrobuprenorphine. Labels at positions 15 and 16 of the morphine skeleton proved to be sufficiently stable under strong acidic or basic conditions.
AB - Tritium labelling of buprenorphine, a mixed agonist-antagonist opioid ligand, was performed with a specific activity of 2.35 TBq/mmol (63.6 Ci/mmol) starting with 15,16-didehydrobuprenorphine. Labels at positions 15 and 16 of the morphine skeleton proved to be sufficiently stable under strong acidic or basic conditions.
KW - 15,16-Didehydrobuprenorphine
KW - Buprenorphine
KW - Opioid ligand
KW - Tritiation
UR - http://www.scopus.com/inward/record.url?scp=0028896723&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028896723&partnerID=8YFLogxK
U2 - 10.1002/jlcr.2580360110
DO - 10.1002/jlcr.2580360110
M3 - Article
VL - 36
SP - 79
EP - 83
JO - Journal of Labelled Compounds and Radiopharmaceuticals
JF - Journal of Labelled Compounds and Radiopharmaceuticals
SN - 0362-4803
IS - 1
ER -