Synthesis of Garugamblin‐2, a Macrocyclic Diarylheptanoid Constituent of Garuga gamblei

György M. Keserü, Mihály Nógrádi, M. Kajtár-Peredy

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17 Citations (Scopus)

Abstract

The macrocyclic diarylheptanoid garugamblin‐2 (1) and its constitutional and sterical isomers 17–19 were synthesized using the isoxazole derivative 8 for the introduction of the β‐methoxyenone function. Ring closure was accomplished by an intramolecular Wittig reaction. (Formula Presented.)

Original languageEnglish
Pages (from-to)361-364
Number of pages4
JournalLiebigs Annalen der Chemie
Volume1994
Issue number4
DOIs
Publication statusPublished - 1994

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Keywords

  • Calculations, MMX, PM3
  • Diarylheptanoids
  • Garuga gamblei
  • Garugamblin‐2
  • Macrocycles

ASJC Scopus subject areas

  • Medicine(all)

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