Synthesis of Fluorine-Containing Molecular Entities Through Fluoride Ring Opening of Oxiranes and Aziridines

Attila Márió Remete, L. Kiss

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The current minireview highlights the most relevant methodologies for the creation of fluorinated scaffolds accessed through transformations of three-membered heterocycles (oxiranes and aziridines) involving their opening with various nucleophilic fluorinating agents reported over recent years. The purpose of the review is also to provide an overview of the ring-opening synthetic practices with fluoride towards different functionalized, fluorine-containing scaffolds with the focus on regioselectivity/regiocontrol and enantioselectivity including symmetric or unsymmetric monoheterocycles, cycloalkane-fused oxiranes and aziridines.

Original languageEnglish
JournalEuropean Journal of Organic Chemistry
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Aziridines
Fluorine
Epoxy Compounds
Fluorides
Scaffolds
fluorine
fluorides
Cycloparaffins
Regioselectivity
Enantioselectivity
rings
synthesis
methodology

Keywords

  • Aziridines
  • Fluorination
  • Oxiranes
  • Ring opening
  • Selectivity

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

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AB - The current minireview highlights the most relevant methodologies for the creation of fluorinated scaffolds accessed through transformations of three-membered heterocycles (oxiranes and aziridines) involving their opening with various nucleophilic fluorinating agents reported over recent years. The purpose of the review is also to provide an overview of the ring-opening synthetic practices with fluoride towards different functionalized, fluorine-containing scaffolds with the focus on regioselectivity/regiocontrol and enantioselectivity including symmetric or unsymmetric monoheterocycles, cycloalkane-fused oxiranes and aziridines.

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