Synthesis of fluorinated amino acid derivatives through late-stage deoxyfluorinations

Attila Márió Remete, Melinda Nonn, Santos Fustero, F. Fülöp, L. Kiss

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Fluorine chemistry has represented a hot topic in drug research over the last decade. Because of their pharmaceutical potential, fluorine-containing amino acids and related derivatives have acquired high importance among medicinal chemists. Therefore their synthesis and the development of various synthetic methods for these types of molecular scaffolds have gained increasing interest in synthetic organic chemistry. The current review focuses on synthetic protocols towards fluorine-containing amino acid derivatives through late-stage fluorination with various nucleophilic reagents, describing the access of various open-chain and cyclic α-, β-, γ-amino acid derivatives.

Original languageEnglish
Pages (from-to)6367-6418
Number of pages52
JournalTetrahedron
Volume74
Issue number44
DOIs
Publication statusPublished - Nov 1 2018

Keywords

  • Alicyclic compounds
  • Amino acids
  • Fluorination
  • Fluorine
  • Nucleophile

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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