Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities

Attila Sipos, Gábor Máté, Erzsébet Rth, Anikó Borbás, Gyula Batta, Ilona Bereczki, Sándor Kéki, István Jóna, Eszter Ostorházi, Ferenc Rozgonyi, Evelien Vanderlinden, Lieve Naesens, Pál Herczegh

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8 Citations (Scopus)

Abstract

Isoindole and benzoisoindole derivatives of ristocetin aglycon have been prepared by reaction with o-phthalaldehyde or naphthalene-2,3-dialdehyde and various thiols. The new compounds exhibited potent antibacterial and anti-influenza virus activity. The cluster forming and fluorescent properties of the aglycon derivatives were also studied.

Original languageEnglish
Pages (from-to)361-367
Number of pages7
JournalEuropean Journal of Medicinal Chemistry
Volume58
DOIs
Publication statusPublished - Dec 1 2012

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Keywords

  • Aggregation
  • Antibacterial
  • Antiviral
  • Fluorescence
  • Glycopeptide
  • Multivalence

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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