Synthesis of ethyl octyl α-aminophosphonate derivatives

Ádám Tajti, Erika Bálint, G. Keglevich

Research output: Contribution to journalArticle

15 Citations (Scopus)


Ethyl octyl phosphite (EOP), a dialkyl phosphite with mixed alkyl groups was prepared, and utilized in the Kabachnik-Fields reaction. The condensation of EOP, paraformaldehyde and primary or secondary amines used in equimolar quantities afforded new α-Aminophosphonates under microwave conditions. Methylation of the α-(alkylamino) phosphonates was also investigated. The double phospha-Mannich reaction of primary amines and two equivalents of EOP and paraformaldehyde furnished new bis(phosphonomethyl)amines.

Original languageEnglish
Pages (from-to)638-645
Number of pages8
JournalCurrent Organic Synthesis
Issue number4
Publication statusPublished - Aug 1 2016


  • Ethyl octyl phosphite
  • Ethyl octyl α-aminomethyl-phosphonates
  • Kabachnik-fields reaction
  • Microwave
  • N, N-bis(ethyloctylphosphonoylmethyl) amines

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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