Halogéntartalmú és heterociklusos ösztronszármazékok szintézise

Translated title of the contribution: Synthesis of estrone derivatives containing different halogens and/or heterocyclic moiety

Research output: Contribution to journalArticle

Abstract

New compounds derived from the 3-methyl and 3-benzyl ethers of a D-secoestrone aldehyde were synthetized. In the presence of different Lewis acids D-homosteroids could form. These reactions which can be explained by an intramolecular Prins-type mechanism follow high stereoselectivity and reactivity and lead to compounds containing 16β-oriented halogens in the sterane skeleton. The formation and reaction of the imines derived from the aldehyde and aniline as well as substituted anilines provide a highly efficient access to steroid derivatives. The steroid alkaloids are of pharmacological interest.

Translated title of the contributionSynthesis of estrone derivatives containing different halogens and/or heterocyclic moiety
Original languageHungarian
Pages (from-to)441-447
Number of pages7
JournalActa pharmaceutica Hungarica
Volume71
Issue number4
Publication statusPublished - Dec 1 2001

ASJC Scopus subject areas

  • Pharmaceutical Science

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