Synthesis of Derivatives of 2, 6-Dideoxy-2, 2-Difluoro-3-O-Methyl-L-Arsbinopyranose (2, 2-Difluorooeandrose)

Christophe Bliard, Pal Herczegh, Alain Olesker, Gabor Lukacs

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

L-Oleandrose is the carbohydrate constituent of the potent anthelmintic agents the avermectins. Diethylaminosulfur tri-fluoride treatment of appropriate uloses did not give gem-di-fluoro sugars. Trifluorofluoroxymethane or xenon difluoride the double bond of 4-0-benzoyl-6-deoxy-2-fluoro-3-0-methyl-L-glucal produced protected 2, 2-difluorooleandrose derivatives activated at their anomeric center and ready for glyco-sidation.

Original languageEnglish
Pages (from-to)103-113
Number of pages11
JournalJournal of Carbohydrate Chemistry
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 1 1989

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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