L-Oleandrose is the carbohydrate constituent of the potent anthelmintic agents the avermectins. Diethylaminosulfur tri-fluoride treatment of appropriate uloses did not give gem-di-fluoro sugars. Trifluorofluoroxymethane or xenon difluoride the double bond of 4-0-benzoyl-6-deoxy-2-fluoro-3-0-methyl-L-glucal produced protected 2, 2-difluorooleandrose derivatives activated at their anomeric center and ready for glyco-sidation.
ASJC Scopus subject areas
- Organic Chemistry