Synthesis of daunomycin-oligoarginine conjugates and their effect on human leukemia cells (HL-60)

Z. Bánóczi, Balázs Peregi, Erika Orbán, Rita Szabó, F. Hudecz

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The synthesis of new daunomycin-conjugates, i.e. succinyl derivative of daunomycin (DauSuc) coupled to oligoarginine (Argn, n=4, 6 or 8) is described. These compounds are stable to certain conditions used for in vitro cellular experiments. All conjugates depending on the number of Arg residues possess antiproliferative effect against sensitive and MDR1 resistant human leukemia (HL-60) cells. DauSucArg8 and DauSucArg6 were more efficient than free DauSuc. Uptake studies show that conjugates are entering both sensitive and MDR1 resistant HL-60 cells.

Original languageEnglish
Pages (from-to)140-153
Number of pages14
JournalArkivoc
Volume2008
Issue number3
Publication statusPublished - Feb 17 2008

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Daunorubicin
Derivatives
Experiments

Keywords

  • Antitumor effect
  • Cell-penetrating peptide
  • Daunomycin
  • Daunomycin conjugates
  • Oligoarginine

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis of daunomycin-oligoarginine conjugates and their effect on human leukemia cells (HL-60). / Bánóczi, Z.; Peregi, Balázs; Orbán, Erika; Szabó, Rita; Hudecz, F.

In: Arkivoc, Vol. 2008, No. 3, 17.02.2008, p. 140-153.

Research output: Contribution to journalArticle

Bánóczi, Z. ; Peregi, Balázs ; Orbán, Erika ; Szabó, Rita ; Hudecz, F. / Synthesis of daunomycin-oligoarginine conjugates and their effect on human leukemia cells (HL-60). In: Arkivoc. 2008 ; Vol. 2008, No. 3. pp. 140-153.
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