Synthesis of D-seco-13α-androst-5-ene derivatives

János Wölfling, Ágota Szájli, László Vörös, Mónika Gáspár, Gyula Schneider

Research output: Contribution to journalArticle

7 Citations (Scopus)


3β-Hydroxy-16,17-seco-13α-androsta-5,16-dien-17-al was obtained from 3β-acetoxyandrost-5-en-17-one in six steps with a Grob fragmentation as the key step. This seco-steroid, containing a formyl group and an unsaturated side-chain in a sterically favourable cis position, is a useful synthon for the synthesis of novel heterocycles condensed to the 3β-hydroxy-13α- androst-5-en-17-one skeleton.

Original languageEnglish
Pages (from-to)1099-1107
Number of pages9
JournalMonatshefte fur Chemie
Issue number8
Publication statusPublished - Aug 1 2006


  • 3α-Androst-5-en-17-one
  • Chirality
  • Grob fragmentation
  • Natural products
  • Steroids

ASJC Scopus subject areas

  • Chemistry(all)

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