Synthesis of D-seco-13α-androst-5-ene derivatives

J. Wölfling, Ágota Szájli, László Vörös, Mónika Gáspár, G. Schneider

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

3β-Hydroxy-16,17-seco-13α-androsta-5,16-dien-17-al was obtained from 3β-acetoxyandrost-5-en-17-one in six steps with a Grob fragmentation as the key step. This seco-steroid, containing a formyl group and an unsaturated side-chain in a sterically favourable cis position, is a useful synthon for the synthesis of novel heterocycles condensed to the 3β-hydroxy-13α- androst-5-en-17-one skeleton.

Original languageEnglish
Pages (from-to)1099-1107
Number of pages9
JournalMonatshefte fur Chemie
Volume137
Issue number8
DOIs
Publication statusPublished - Aug 2006

Fingerprint

Steroids
Derivatives
androst-5-en-17-one

Keywords

  • 3α-Androst-5-en-17-one
  • Chirality
  • Grob fragmentation
  • Natural products
  • Steroids

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Synthesis of D-seco-13α-androst-5-ene derivatives. / Wölfling, J.; Szájli, Ágota; Vörös, László; Gáspár, Mónika; Schneider, G.

In: Monatshefte fur Chemie, Vol. 137, No. 8, 08.2006, p. 1099-1107.

Research output: Contribution to journalArticle

Wölfling, J. ; Szájli, Ágota ; Vörös, László ; Gáspár, Mónika ; Schneider, G. / Synthesis of D-seco-13α-androst-5-ene derivatives. In: Monatshefte fur Chemie. 2006 ; Vol. 137, No. 8. pp. 1099-1107.
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