Synthesis of cephalosporins carrying isoxazolyl acetamido and related side chains

F. Sztaricskai, G. Batta, Z. Dinya, Istvan F. Pelyvas, P. Herczegh, Tamas E. Gunda, Istvan Koczka

Research output: Contribution to journalArticle

Abstract

Starting from 3,5-dimethylisoxazole the carboxylic acids I and V, the amino acids VIII (L-) and IX (D-), and the ureido acids X (L-) and XI (D-) were prepared, which were used for the synthesis of the new cephalosporins XVIIb, XXa-c (L-), and XXIb (D-). The in vitro antibacterial activity of these semi-synthetic antibiotics was studied. The resorption of XVIIb was investigated in mice.

Original languageEnglish
Pages (from-to)1296-1307
Number of pages12
JournalChemistry of Heterocyclic Compounds
Volume34
Issue number11
Publication statusPublished - Nov 1998

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Cephalosporins
Carboxylic Acids
Anti-Bacterial Agents
Amino Acids
Acids

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis of cephalosporins carrying isoxazolyl acetamido and related side chains. / Sztaricskai, F.; Batta, G.; Dinya, Z.; Pelyvas, Istvan F.; Herczegh, P.; Gunda, Tamas E.; Koczka, Istvan.

In: Chemistry of Heterocyclic Compounds, Vol. 34, No. 11, 11.1998, p. 1296-1307.

Research output: Contribution to journalArticle

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