Synthesis of carotenoid-monosaccharide conjugates via azide–alkyne click-reaction

Attila Agócs, Éva Bokor, Anikó Takátsy, Tamás Lóránd, József Deli, László Somsák, V. Nagy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Carotenoid pentynoates were coupled to protected and unprotected sugar azides via an azide-alkyne click-reaction using bis-triphenylphosphano-copper(I)-butyrate (C3H7COOCu(PPh3)2) complex. Protected sugars delivered the conjugates with excellent yields, whereas with unprotected ones amphipathic carotenoid-sugar derivatives were obtained in good or moderate yields in a simple way.

Original languageEnglish
Pages (from-to)519-526
Number of pages8
JournalTetrahedron
Volume73
Issue number5
DOIs
Publication statusPublished - Feb 2 2017

Fingerprint

Azides
Monosaccharides
Carotenoids
Sugars
Alkynes
Butyrates
Copper
Derivatives

Keywords

  • Amphipathic
  • Carotenoid pentynoates
  • Click reaction
  • Glycosides
  • Unprotected sugar

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Agócs, A., Bokor, É., Takátsy, A., Lóránd, T., Deli, J., Somsák, L., & Nagy, V. (2017). Synthesis of carotenoid-monosaccharide conjugates via azide–alkyne click-reaction. Tetrahedron, 73(5), 519-526. https://doi.org/10.1016/j.tet.2016.12.035

Synthesis of carotenoid-monosaccharide conjugates via azide–alkyne click-reaction. / Agócs, Attila; Bokor, Éva; Takátsy, Anikó; Lóránd, Tamás; Deli, József; Somsák, László; Nagy, V.

In: Tetrahedron, Vol. 73, No. 5, 02.02.2017, p. 519-526.

Research output: Contribution to journalArticle

Agócs, A, Bokor, É, Takátsy, A, Lóránd, T, Deli, J, Somsák, L & Nagy, V 2017, 'Synthesis of carotenoid-monosaccharide conjugates via azide–alkyne click-reaction', Tetrahedron, vol. 73, no. 5, pp. 519-526. https://doi.org/10.1016/j.tet.2016.12.035
Agócs A, Bokor É, Takátsy A, Lóránd T, Deli J, Somsák L et al. Synthesis of carotenoid-monosaccharide conjugates via azide–alkyne click-reaction. Tetrahedron. 2017 Feb 2;73(5):519-526. https://doi.org/10.1016/j.tet.2016.12.035
Agócs, Attila ; Bokor, Éva ; Takátsy, Anikó ; Lóránd, Tamás ; Deli, József ; Somsák, László ; Nagy, V. / Synthesis of carotenoid-monosaccharide conjugates via azide–alkyne click-reaction. In: Tetrahedron. 2017 ; Vol. 73, No. 5. pp. 519-526.
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