Synthesis of carotenoid-cysteine conjugates

Afshin Zand, Attila Agócs, J. Deli, V. Nagy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Isozeaxanthin under acidic conditions forms an allylic cation which reacts readily with thiol nucleophiles. With N-acetylcysteine as a nucleophile the products obtained are carotenoid-cysteine conjugates in which the amino acid moiety is attached to the carotenoid via sulphur in position 4. The water solubility of the products can be increased by deprotection of the amino group. The antioxidant activity of the products were examined on human liver cells under conditions of hydrogen-peroxide induced oxidative stress.

Original languageEnglish
Pages (from-to)149-150
Number of pages2
JournalActa Biochimica Polonica
Volume59
Issue number1
Publication statusPublished - 2012

Fingerprint

Nucleophiles
Carotenoids
Cysteine
Oxidative stress
Acetylcysteine
Sulfur
Sulfhydryl Compounds
Liver
Solubility
Hydrogen Peroxide
Cations
Oxidative Stress
Antioxidants
Amino Acids
Water

Keywords

  • Cell membrane
  • Cysteine
  • Isozeaxanthin
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Synthesis of carotenoid-cysteine conjugates. / Zand, Afshin; Agócs, Attila; Deli, J.; Nagy, V.

In: Acta Biochimica Polonica, Vol. 59, No. 1, 2012, p. 149-150.

Research output: Contribution to journalArticle

Zand, A, Agócs, A, Deli, J & Nagy, V 2012, 'Synthesis of carotenoid-cysteine conjugates', Acta Biochimica Polonica, vol. 59, no. 1, pp. 149-150.
Zand, Afshin ; Agócs, Attila ; Deli, J. ; Nagy, V. / Synthesis of carotenoid-cysteine conjugates. In: Acta Biochimica Polonica. 2012 ; Vol. 59, No. 1. pp. 149-150.
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