Synthesis of bridged isoflavone derivatives

Research output: Contribution to journalArticle

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Abstract

7-Chloroalkoxyisoflavones (10-26) have been prepared by chemoselective-in the case of 5,7-dihydroxyisoflavones also regioselective-alkylation of hydroxyisoflavones (3-9) with α-bromo-ω-chloroalkanes. Compounds 10-26 were allowed to react either with 2′,4′-dihydroxy-3′-n-propylacetophenone (1) or with 2-ethoxycarbonyl-7-hydroxy-8-n-propylchromone (2) to afford bridged isoflavone derivatives 27-51 with methylene spacers of various length. Carboxylic acid ethyl esters 43-51 have been saponified to obtain the carboxylic acids 52-60.

Original languageEnglish
Pages (from-to)219-226
Number of pages8
JournalMonatshefte fur Chemie
Volume126
Issue number2
DOIs
Publication statusPublished - Feb 1995

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Isoflavones
Carboxylic Acids
Alkylation
Esters

Keywords

  • 2-Carboxychromone derivatives
  • 7-Chloroalkoxyisoflavones
  • 7-Hydroxyisoflavones
  • H NMR spectroscopy

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Synthesis of bridged isoflavone derivatives. / Lévai, A.; Patonay, T.

In: Monatshefte fur Chemie, Vol. 126, No. 2, 02.1995, p. 219-226.

Research output: Contribution to journalArticle

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