Synthesis of biocompatible nanocomposite hydrogels as a local drug delivery system

Jozsef Bako, Marta Szepesi, Adrienn J. Veres, C. Cserháti, Zsuzsa M. Borbely, Csaba Hegedus, J. Borbély

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Nanocomposite biocompatible hydrogels (NCHG) were synthesised as model systems for in situ cured potentially local drug delivery devices for curing periodontal infections. The composite consists of the following components: nanoparticles (NPs), matrix gel, and chlorhexidine (CHX) as antibacterial drug. The NPs were obtained by free radical initiated copolymerization of the monomers, 2-hydroxyethyl methacrylate (HEMA) and polyethyleneglycol dimethacrylate (PEGDMA), in aqueous solution. The same monomers were used to prepare crosslinked matrices by photopolymerization. NCHGs were obtained by mixing NPs, monomers, and drug in an aqueous solution then crosslinked by photopolymerization. Mechanical properties, swelling behavior, and the kinetics of drug release have been investigated. It was found that compression strength values increased with increasing ratio of the crosslinker PEGDMA. Incorporation of NPs into the matrix resulted similar compression strength as the matrix hydrogel. The hydrated NCHGs swelled more slowly but admitted more water. The drug was incorporated in NPs by swelling in CHX aqueous solution or added to the solution of monomer mixture followed by photopolymerization. Studies of release kinetics revealed that on average 60% of the loaded drug was released. The most rapid release was observed over a 24 h period for matrix gels with low crosslinking density. For NCHGs, the release period exceeded 48 h. An unexpected result was observed for NCHGs without drug in the NPs. In this case, increasing release was observed for the first 24 h. Thereafter, however, the apparent quantity of detectable drug decreased dramatically.

Original languageEnglish
Pages (from-to)357-363
Number of pages7
JournalColloid & Polymer Science
Volume286
Issue number3
DOIs
Publication statusPublished - Mar 2008

Fingerprint

Hydrogels
delivery
Nanocomposites
nanocomposites
drugs
Nanoparticles
Photopolymerization
synthesis
Monomers
Pharmaceutical Preparations
nanoparticles
monomers
Chlorhexidine
matrices
Swelling
Gels
aqueous solutions
swelling
Kinetics
gels

Keywords

  • Chlorhexidinediguconate
  • Hydrogel
  • Localdrug delivery
  • Nanocomposite
  • Photopolymerization

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Materials Chemistry
  • Colloid and Surface Chemistry

Cite this

Synthesis of biocompatible nanocomposite hydrogels as a local drug delivery system. / Bako, Jozsef; Szepesi, Marta; Veres, Adrienn J.; Cserháti, C.; Borbely, Zsuzsa M.; Hegedus, Csaba; Borbély, J.

In: Colloid & Polymer Science, Vol. 286, No. 3, 03.2008, p. 357-363.

Research output: Contribution to journalArticle

Bako, Jozsef ; Szepesi, Marta ; Veres, Adrienn J. ; Cserháti, C. ; Borbely, Zsuzsa M. ; Hegedus, Csaba ; Borbély, J. / Synthesis of biocompatible nanocomposite hydrogels as a local drug delivery system. In: Colloid & Polymer Science. 2008 ; Vol. 286, No. 3. pp. 357-363.
@article{f7ae3054cd794375ab21a29cc8ec884c,
title = "Synthesis of biocompatible nanocomposite hydrogels as a local drug delivery system",
abstract = "Nanocomposite biocompatible hydrogels (NCHG) were synthesised as model systems for in situ cured potentially local drug delivery devices for curing periodontal infections. The composite consists of the following components: nanoparticles (NPs), matrix gel, and chlorhexidine (CHX) as antibacterial drug. The NPs were obtained by free radical initiated copolymerization of the monomers, 2-hydroxyethyl methacrylate (HEMA) and polyethyleneglycol dimethacrylate (PEGDMA), in aqueous solution. The same monomers were used to prepare crosslinked matrices by photopolymerization. NCHGs were obtained by mixing NPs, monomers, and drug in an aqueous solution then crosslinked by photopolymerization. Mechanical properties, swelling behavior, and the kinetics of drug release have been investigated. It was found that compression strength values increased with increasing ratio of the crosslinker PEGDMA. Incorporation of NPs into the matrix resulted similar compression strength as the matrix hydrogel. The hydrated NCHGs swelled more slowly but admitted more water. The drug was incorporated in NPs by swelling in CHX aqueous solution or added to the solution of monomer mixture followed by photopolymerization. Studies of release kinetics revealed that on average 60{\%} of the loaded drug was released. The most rapid release was observed over a 24 h period for matrix gels with low crosslinking density. For NCHGs, the release period exceeded 48 h. An unexpected result was observed for NCHGs without drug in the NPs. In this case, increasing release was observed for the first 24 h. Thereafter, however, the apparent quantity of detectable drug decreased dramatically.",
keywords = "Chlorhexidinediguconate, Hydrogel, Localdrug delivery, Nanocomposite, Photopolymerization",
author = "Jozsef Bako and Marta Szepesi and Veres, {Adrienn J.} and C. Cserh{\'a}ti and Borbely, {Zsuzsa M.} and Csaba Hegedus and J. Borb{\'e}ly",
year = "2008",
month = "3",
doi = "10.1007/s00396-007-1793-7",
language = "English",
volume = "286",
pages = "357--363",
journal = "Kolloid Zeitschrift",
issn = "0303-402X",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Synthesis of biocompatible nanocomposite hydrogels as a local drug delivery system

AU - Bako, Jozsef

AU - Szepesi, Marta

AU - Veres, Adrienn J.

AU - Cserháti, C.

AU - Borbely, Zsuzsa M.

AU - Hegedus, Csaba

AU - Borbély, J.

PY - 2008/3

Y1 - 2008/3

N2 - Nanocomposite biocompatible hydrogels (NCHG) were synthesised as model systems for in situ cured potentially local drug delivery devices for curing periodontal infections. The composite consists of the following components: nanoparticles (NPs), matrix gel, and chlorhexidine (CHX) as antibacterial drug. The NPs were obtained by free radical initiated copolymerization of the monomers, 2-hydroxyethyl methacrylate (HEMA) and polyethyleneglycol dimethacrylate (PEGDMA), in aqueous solution. The same monomers were used to prepare crosslinked matrices by photopolymerization. NCHGs were obtained by mixing NPs, monomers, and drug in an aqueous solution then crosslinked by photopolymerization. Mechanical properties, swelling behavior, and the kinetics of drug release have been investigated. It was found that compression strength values increased with increasing ratio of the crosslinker PEGDMA. Incorporation of NPs into the matrix resulted similar compression strength as the matrix hydrogel. The hydrated NCHGs swelled more slowly but admitted more water. The drug was incorporated in NPs by swelling in CHX aqueous solution or added to the solution of monomer mixture followed by photopolymerization. Studies of release kinetics revealed that on average 60% of the loaded drug was released. The most rapid release was observed over a 24 h period for matrix gels with low crosslinking density. For NCHGs, the release period exceeded 48 h. An unexpected result was observed for NCHGs without drug in the NPs. In this case, increasing release was observed for the first 24 h. Thereafter, however, the apparent quantity of detectable drug decreased dramatically.

AB - Nanocomposite biocompatible hydrogels (NCHG) were synthesised as model systems for in situ cured potentially local drug delivery devices for curing periodontal infections. The composite consists of the following components: nanoparticles (NPs), matrix gel, and chlorhexidine (CHX) as antibacterial drug. The NPs were obtained by free radical initiated copolymerization of the monomers, 2-hydroxyethyl methacrylate (HEMA) and polyethyleneglycol dimethacrylate (PEGDMA), in aqueous solution. The same monomers were used to prepare crosslinked matrices by photopolymerization. NCHGs were obtained by mixing NPs, monomers, and drug in an aqueous solution then crosslinked by photopolymerization. Mechanical properties, swelling behavior, and the kinetics of drug release have been investigated. It was found that compression strength values increased with increasing ratio of the crosslinker PEGDMA. Incorporation of NPs into the matrix resulted similar compression strength as the matrix hydrogel. The hydrated NCHGs swelled more slowly but admitted more water. The drug was incorporated in NPs by swelling in CHX aqueous solution or added to the solution of monomer mixture followed by photopolymerization. Studies of release kinetics revealed that on average 60% of the loaded drug was released. The most rapid release was observed over a 24 h period for matrix gels with low crosslinking density. For NCHGs, the release period exceeded 48 h. An unexpected result was observed for NCHGs without drug in the NPs. In this case, increasing release was observed for the first 24 h. Thereafter, however, the apparent quantity of detectable drug decreased dramatically.

KW - Chlorhexidinediguconate

KW - Hydrogel

KW - Localdrug delivery

KW - Nanocomposite

KW - Photopolymerization

UR - http://www.scopus.com/inward/record.url?scp=40449129171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40449129171&partnerID=8YFLogxK

U2 - 10.1007/s00396-007-1793-7

DO - 10.1007/s00396-007-1793-7

M3 - Article

AN - SCOPUS:40449129171

VL - 286

SP - 357

EP - 363

JO - Kolloid Zeitschrift

JF - Kolloid Zeitschrift

SN - 0303-402X

IS - 3

ER -