Synthesis of biocompatible nanocomposite hydrogel as a local drug delivery system

J. Bako, M. Szepesi, Z. M. Borbely, C. Hegedus, J. Borbély

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nanocomposite biocompatible hydrogels (NCHG) were synthesised as model systems for in situ cured potentially local drug delivery devices for curing periodontal infections. The composite consists of the following components', nanoparticles (NPs), matrix gel, and Chlorhexidine (CHX) as antibacterial drug. The NPs were obtained by free radical initiated copolymerization of the monomers, 2-hydroxyethyl methacrylate (HEMA) and polyethyleneglycol dimethacrylate (PEGDMA), in aqueous solution. The same monomers were used to prepare crosslinked matrices by photopolymerization. NCHGs were obtained by mixing NPs, monomers, and drug in an aqueous solution then crosslinked by photopolymerization. Studies of release kinetics revealed that on average 60% of the loaded drug was released. The most rapid release was observed over a 24 hour period for matrix gels with low crosslinking density. For NCHGs the release period exceeded 48 hours.

Original languageEnglish
Title of host publication2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Pages409-412
Number of pages4
Volume2
Publication statusPublished - 2007
Event2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 - Santa Clara, CA, United States
Duration: May 20 2007May 24 2007

Other

Other2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007
CountryUnited States
CitySanta Clara, CA
Period5/20/075/24/07

Fingerprint

Hydrogels
Nanocomposites
Photopolymerization
Monomers
Nanoparticles
Gels
Free radicals
Drug delivery
Crosslinking
Copolymerization
Curing
Kinetics
Composite materials
Drug Delivery Systems

Keywords

  • Chlorhexidine diguconate
  • Hydrogel
  • Local drug delivery
  • Nanocomposite
  • Photopolymerization

ASJC Scopus subject areas

  • Mechanical Engineering

Cite this

Bako, J., Szepesi, M., Borbely, Z. M., Hegedus, C., & Borbély, J. (2007). Synthesis of biocompatible nanocomposite hydrogel as a local drug delivery system. In 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings (Vol. 2, pp. 409-412)

Synthesis of biocompatible nanocomposite hydrogel as a local drug delivery system. / Bako, J.; Szepesi, M.; Borbely, Z. M.; Hegedus, C.; Borbély, J.

2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings. Vol. 2 2007. p. 409-412.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bako, J, Szepesi, M, Borbely, ZM, Hegedus, C & Borbély, J 2007, Synthesis of biocompatible nanocomposite hydrogel as a local drug delivery system. in 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings. vol. 2, pp. 409-412, 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Santa Clara, CA, United States, 5/20/07.
Bako J, Szepesi M, Borbely ZM, Hegedus C, Borbély J. Synthesis of biocompatible nanocomposite hydrogel as a local drug delivery system. In 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings. Vol. 2. 2007. p. 409-412
Bako, J. ; Szepesi, M. ; Borbely, Z. M. ; Hegedus, C. ; Borbély, J. / Synthesis of biocompatible nanocomposite hydrogel as a local drug delivery system. 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings. Vol. 2 2007. pp. 409-412
@inproceedings{1caf401c9510479d913269b41672b1dd,
title = "Synthesis of biocompatible nanocomposite hydrogel as a local drug delivery system",
abstract = "Nanocomposite biocompatible hydrogels (NCHG) were synthesised as model systems for in situ cured potentially local drug delivery devices for curing periodontal infections. The composite consists of the following components', nanoparticles (NPs), matrix gel, and Chlorhexidine (CHX) as antibacterial drug. The NPs were obtained by free radical initiated copolymerization of the monomers, 2-hydroxyethyl methacrylate (HEMA) and polyethyleneglycol dimethacrylate (PEGDMA), in aqueous solution. The same monomers were used to prepare crosslinked matrices by photopolymerization. NCHGs were obtained by mixing NPs, monomers, and drug in an aqueous solution then crosslinked by photopolymerization. Studies of release kinetics revealed that on average 60{\%} of the loaded drug was released. The most rapid release was observed over a 24 hour period for matrix gels with low crosslinking density. For NCHGs the release period exceeded 48 hours.",
keywords = "Chlorhexidine diguconate, Hydrogel, Local drug delivery, Nanocomposite, Photopolymerization",
author = "J. Bako and M. Szepesi and Borbely, {Z. M.} and C. Hegedus and J. Borb{\'e}ly",
year = "2007",
language = "English",
isbn = "1420063421",
volume = "2",
pages = "409--412",
booktitle = "2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings",

}

TY - GEN

T1 - Synthesis of biocompatible nanocomposite hydrogel as a local drug delivery system

AU - Bako, J.

AU - Szepesi, M.

AU - Borbely, Z. M.

AU - Hegedus, C.

AU - Borbély, J.

PY - 2007

Y1 - 2007

N2 - Nanocomposite biocompatible hydrogels (NCHG) were synthesised as model systems for in situ cured potentially local drug delivery devices for curing periodontal infections. The composite consists of the following components', nanoparticles (NPs), matrix gel, and Chlorhexidine (CHX) as antibacterial drug. The NPs were obtained by free radical initiated copolymerization of the monomers, 2-hydroxyethyl methacrylate (HEMA) and polyethyleneglycol dimethacrylate (PEGDMA), in aqueous solution. The same monomers were used to prepare crosslinked matrices by photopolymerization. NCHGs were obtained by mixing NPs, monomers, and drug in an aqueous solution then crosslinked by photopolymerization. Studies of release kinetics revealed that on average 60% of the loaded drug was released. The most rapid release was observed over a 24 hour period for matrix gels with low crosslinking density. For NCHGs the release period exceeded 48 hours.

AB - Nanocomposite biocompatible hydrogels (NCHG) were synthesised as model systems for in situ cured potentially local drug delivery devices for curing periodontal infections. The composite consists of the following components', nanoparticles (NPs), matrix gel, and Chlorhexidine (CHX) as antibacterial drug. The NPs were obtained by free radical initiated copolymerization of the monomers, 2-hydroxyethyl methacrylate (HEMA) and polyethyleneglycol dimethacrylate (PEGDMA), in aqueous solution. The same monomers were used to prepare crosslinked matrices by photopolymerization. NCHGs were obtained by mixing NPs, monomers, and drug in an aqueous solution then crosslinked by photopolymerization. Studies of release kinetics revealed that on average 60% of the loaded drug was released. The most rapid release was observed over a 24 hour period for matrix gels with low crosslinking density. For NCHGs the release period exceeded 48 hours.

KW - Chlorhexidine diguconate

KW - Hydrogel

KW - Local drug delivery

KW - Nanocomposite

KW - Photopolymerization

UR - http://www.scopus.com/inward/record.url?scp=34547995468&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547995468&partnerID=8YFLogxK

M3 - Conference contribution

SN - 1420063421

SN - 9781420063424

SN - 1420061836

SN - 9781420061833

VL - 2

SP - 409

EP - 412

BT - 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings

ER -