Synthesis of biocompatible nanocomposite hydrogel as a local drug delivery system

J. Bako, M. Szepesi, Z. M. Borbely, C. Hegedus, J. Borbely

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nanocomposite biocompatible hydrogels (NCHG) were synthesised as model systems for in situ cured potentially local drug delivery devices for curing periodontal infections. The composite consists of the following components', nanoparticles (NPs), matrix gel, and Chlorhexidine (CHX) as antibacterial drug. The NPs were obtained by free radical initiated copolymerization of the monomers, 2-hydroxyethyl methacrylate (HEMA) and polyethyleneglycol dimethacrylate (PEGDMA), in aqueous solution. The same monomers were used to prepare crosslinked matrices by photopolymerization. NCHGs were obtained by mixing NPs, monomers, and drug in an aqueous solution then crosslinked by photopolymerization. Studies of release kinetics revealed that on average 60% of the loaded drug was released. The most rapid release was observed over a 24 hour period for matrix gels with low crosslinking density. For NCHGs the release period exceeded 48 hours.

Original languageEnglish
Title of host publication2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Pages409-412
Number of pages4
Publication statusPublished - Aug 23 2007
Event2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007 - Santa Clara, CA, United States
Duration: May 20 2007May 24 2007

Publication series

Name2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings
Volume2

Other

Other2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007
CountryUnited States
CitySanta Clara, CA
Period5/20/075/24/07

Keywords

  • Chlorhexidine diguconate
  • Hydrogel
  • Local drug delivery
  • Nanocomposite
  • Photopolymerization

ASJC Scopus subject areas

  • Mechanical Engineering

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  • Cite this

    Bako, J., Szepesi, M., Borbely, Z. M., Hegedus, C., & Borbely, J. (2007). Synthesis of biocompatible nanocomposite hydrogel as a local drug delivery system. In 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings (pp. 409-412). (2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007, Technical Proceedings; Vol. 2).