Synthesis of aryl 2,2,2-trifluoroethyl sulfides

Bálint Menczinger, Anikó Nemes, Dénes Szabó, Gitta Schlosser, Tamás Jernei, Antal Csámpai, József Rábai

Research output: Contribution to journalArticle


Aryl 2,2,2-trifluoroethyl sulfides were synthesized by copper(I)-catalyzed nucleophilic aromatic substitution reaction (Goldberg-Ullmann coupling). The method requires aryl iodides and 2,2,2-trifluoroethyl thioacetate as starting materials, benzylamine as solvent and base, and copper(I) bromide as a catalyst. The reaction mixture was stirred at 110 °C for 6 h under inert atmosphere to afford the targeted aryl 2,2,2-trifluoroethyl sulfides in moderate to good yield.

Original languageEnglish
Article number109464
JournalJournal of Fluorine Chemistry
Publication statusPublished - Mar 2020



  • Aryl iodides
  • Copper catalyst
  • Fluorine
  • S-Arylation
  • Substitution
  • Trifluoroethylthiolation

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Chemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Menczinger, B., Nemes, A., Szabó, D., Schlosser, G., Jernei, T., Csámpai, A., & Rábai, J. (2020). Synthesis of aryl 2,2,2-trifluoroethyl sulfides. Journal of Fluorine Chemistry, 231, [109464].