Synthesis of Analogues of Thyrotropin‐Releasing Hormone

Cs Somlai, L. Baláspiri

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Abstract

The synthesis of ten new thyrotropin‐releasing hormone analogues (15–24) which contain uncoded amino acids (L‐ and D‐homoleucine, L‐ and D‐homophenylalanine, L‐homoproline and 6‐ketopipecolic acid) is described here. The peptide bond formation was achieved in solution phase using pentafluorophenyl ester activation of the N‐protected amino acids. The analogues were tested for their ability to release thyrotropin and for CNS activities and proved to be fully inactive.

Original languageEnglish
Pages (from-to)525-529
Number of pages5
JournalJournal für Praktische Chemie/Chemiker‐Zeitung
Volume336
Issue number6
DOIs
Publication statusPublished - 1994

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ASJC Scopus subject areas

  • Chemistry(all)

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