Synthesis of Analogues of Thyrotropin‐Releasing Hormone

C. Somlai, L. Baláspiri

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The synthesis of ten new thyrotropin‐releasing hormone analogues (15–24) which contain uncoded amino acids (L‐ and D‐homoleucine, L‐ and D‐homophenylalanine, L‐homoproline and 6‐ketopipecolic acid) is described here. The peptide bond formation was achieved in solution phase using pentafluorophenyl ester activation of the N‐protected amino acids. The analogues were tested for their ability to release thyrotropin and for CNS activities and proved to be fully inactive.

Original languageEnglish
Pages (from-to)525-529
Number of pages5
JournalJournal für Praktische Chemie/Chemiker‐Zeitung
Volume336
Issue number6
DOIs
Publication statusPublished - 1994

Fingerprint

Hormones
Amino acids
Amino Acids
Thyrotropin
Peptides
Esters
Chemical activation
Acids

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

Cite this

Synthesis of Analogues of Thyrotropin‐Releasing Hormone. / Somlai, C.; Baláspiri, L.

In: Journal für Praktische Chemie/Chemiker‐Zeitung, Vol. 336, No. 6, 1994, p. 525-529.

Research output: Contribution to journalArticle

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