Synthesis of alkyl α-aminomethyl-phenylphosphinates and N,N-bis(alkoxyphenylphosphinylmethyl)amines by the microwave-assisted Kabachnik–Fields reaction

Erika Bálint, Regina Eszter Tóth, G. Keglevich

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Abstract

As a novel extension, the Kabachnik–Fields reaction was applied to the synthesis of alkyl α-aminomethyl-phenylphosphinates, and the double phospha-Mannich reaction was utilized in the preparation of bis(alkoxyphenylphosphinylmethyl)amines. A total of 27 new aminophosphinate derivatives were synthesized by the microwave-assisted solvent-free condensation of alkyl phenyl-H-phosphinates, paraformaldehyde, and primary or secondary amines. The starting P-species were also prepared under microwave conditions. The formation of the N-methylated aminomethyl-phenylphosphinate by-products was also investigated.

Original languageEnglish
Pages (from-to)323-335
Number of pages13
JournalHeteroatom Chemistry
Volume27
Issue number5
DOIs
Publication statusPublished - Sep 1 2016

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Amines
Microwaves
Byproducts
Condensation
Derivatives
paraform

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  • Chemistry(all)

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Synthesis of alkyl α-aminomethyl-phenylphosphinates and N,N-bis(alkoxyphenylphosphinylmethyl)amines by the microwave-assisted Kabachnik–Fields reaction. / Bálint, Erika; Tóth, Regina Eszter; Keglevich, G.

In: Heteroatom Chemistry, Vol. 27, No. 5, 01.09.2016, p. 323-335.

Research output: Contribution to journalArticle

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