Synthesis of a sialic acid derivative of ristocetin aglycone as an inhibitor of influenza virus

Ilona Bakai-Bereczki, Mihály Herczeg, Bernadett György, Lieve Naesens, P. Herczegh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In order to promote attachment of the ristocetin aglycone molecule to the surface of the influenza virus, the aglycone was derivatized with a hemagglutinin ligand sialic acid moiety using a click reaction. The sialoristocetin derivative exhibited somewhat lower anti-influenza virus activity than ristocetin and aglycoristocetin.

Original languageEnglish
Pages (from-to)1136-1140
Number of pages5
JournalChemical Papers
Volume69
Issue number8
DOIs
Publication statusPublished - Aug 1 2015

Fingerprint

Ristocetin
N-Acetylneuraminic Acid
Orthomyxoviridae
Viruses
Derivatives
Acids
Hemagglutinins
Ligands
Molecules

Keywords

  • Antiviral activity
  • Influenza virus
  • Ristocetin aglycone
  • Sialoconjugate

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Biochemistry
  • Industrial and Manufacturing Engineering
  • Materials Chemistry

Cite this

Synthesis of a sialic acid derivative of ristocetin aglycone as an inhibitor of influenza virus. / Bakai-Bereczki, Ilona; Herczeg, Mihály; György, Bernadett; Naesens, Lieve; Herczegh, P.

In: Chemical Papers, Vol. 69, No. 8, 01.08.2015, p. 1136-1140.

Research output: Contribution to journalArticle

Bakai-Bereczki, Ilona ; Herczeg, Mihály ; György, Bernadett ; Naesens, Lieve ; Herczegh, P. / Synthesis of a sialic acid derivative of ristocetin aglycone as an inhibitor of influenza virus. In: Chemical Papers. 2015 ; Vol. 69, No. 8. pp. 1136-1140.
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