Synthesis of a coumarin based fluorescent amino acid

Guodong Sui, Péter Kele, Jhony Orbulescu, Qun Huo, Roger M. Leblanc

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

L-2-amino-3-(6,7-dimethoxy-4-coumaryl)-propionic acid (L-Adp), as a non-proteinogenic fluorescent amino acid has been synthesized by a highly stereoselective routine (>99.5%). This fluorescent amino acid, as fluorophore-quencher pair, may be used to study peptide assays. For enantiomeric excess determination, the racemic DL-Adp (DL-2-amino-3-(6,7-dimethoxy-4-coumaryl)-propionic acid) has also been synthesized.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalLetters in Peptide Science
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 2001

Keywords

  • Coumarin
  • Fluorescence spectra
  • Fluorescent label
  • Fluorophore-quencher

ASJC Scopus subject areas

  • Biochemistry

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