Synthesis of a cluster-forming sialylthio-d-galactose fullerene conjugate and evaluation of its interaction with influenza virus hemagglutinin and neuraminidase

Szilvia Tollas, Ilona Bereczki, A. Borbás, G. Batta, Evelien Vanderlinden, Lieve Naesens, P. Herczegh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In order to obtain self assembling, multivalent ligand for influenza virus hemagglutinin α-N-acetylneuraminyl-(2-6)-d-galactopyranose has been synthesized and bonded to a water soluble fullerene derivative using 1,3-dipolar cycloaddition click reaction. The aggregating amphiphilic compound did not inhibit the influenza virus hemagglutinin, but it proved to be an inhibitor of its neuraminidase with a 50% inhibitory concentration of 81 μM.

Original languageEnglish
Pages (from-to)2420-2423
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number11
DOIs
Publication statusPublished - Jun 1 2014

Fingerprint

Fullerenes
Hemagglutinins
Neuraminidase
Orthomyxoviridae
Galactose
Viruses
Cycloaddition
Cycloaddition Reaction
Inhibitory Concentration 50
Ligands
Derivatives
Water

Keywords

  • Aggregation
  • Antiviral activity
  • Fullerene
  • Multivalent ligand
  • Sialic acid
  • Thiodisaccharide

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Medicine(all)

Cite this

Synthesis of a cluster-forming sialylthio-d-galactose fullerene conjugate and evaluation of its interaction with influenza virus hemagglutinin and neuraminidase. / Tollas, Szilvia; Bereczki, Ilona; Borbás, A.; Batta, G.; Vanderlinden, Evelien; Naesens, Lieve; Herczegh, P.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 24, No. 11, 01.06.2014, p. 2420-2423.

Research output: Contribution to journalArticle

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