Synthesis of a cimetidine analogue

József Heiszman, Kálmán Harsányi, L. Tőke

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

2-Hydroxymethyl-4-methylimidazole(2a) and 2, 5-bis(hydroxymethyl)-4-methylimidazole(3a) have been synthesized and characterized. No reaction on the hydroxymethyl moieties in position 2 of these compounds could be observed with cysteamine under usual reaction conditions. The hydroxymethyl group in position 5 of compound 3a does react with cysteamine to give an intermediate leading to 3b and to cimetidine analogue 3c.

Original languageEnglish
Pages (from-to)2487-2491
Number of pages5
JournalHeterocycles
Volume24
Issue number9
Publication statusPublished - Sep 1 1986

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4-methylimidazole
Cysteamine
Cimetidine

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Heiszman, J., Harsányi, K., & Tőke, L. (1986). Synthesis of a cimetidine analogue. Heterocycles, 24(9), 2487-2491.

Synthesis of a cimetidine analogue. / Heiszman, József; Harsányi, Kálmán; Tőke, L.

In: Heterocycles, Vol. 24, No. 9, 01.09.1986, p. 2487-2491.

Research output: Contribution to journalArticle

Heiszman, J, Harsányi, K & Tőke, L 1986, 'Synthesis of a cimetidine analogue', Heterocycles, vol. 24, no. 9, pp. 2487-2491.
Heiszman J, Harsányi K, Tőke L. Synthesis of a cimetidine analogue. Heterocycles. 1986 Sep 1;24(9):2487-2491.
Heiszman, József ; Harsányi, Kálmán ; Tőke, L. / Synthesis of a cimetidine analogue. In: Heterocycles. 1986 ; Vol. 24, No. 9. pp. 2487-2491.
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