Synthesis of 8-Bromoflavone and Its Buchwald-Hartwig Reaction with Amines

Dávid Pajtás, T. Patonay, Krisztina Kónya

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4 Citations (Scopus)

Abstract

Simple and convenient synthesis of 8-bromoflavone was achieved, starting from 2-bromophenol through 3′-bromo-2′-hydroxyacetophenone whose preparation was managed to be solved by optimized Fries rearrangement. The Buchwald-Hartwig reaction of 8-bromoflavone with different type of primary and secondary amines was carried out.

Original languageEnglish
Article numberss-2015-t0461-op
Pages (from-to)97-102
Number of pages6
JournalSynthesis
Volume48
Issue number1
DOIs
Publication statusPublished - Jan 4 2016

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Keywords

  • Buchwald-Hartwig reaction
  • catalysis
  • flavones
  • Fries rearrangement
  • palladium

ASJC Scopus subject areas

  • Organic Chemistry
  • Catalysis

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