Synthesis of 5-substituted indole derivatives. Part 3: A facile synthesis of 5-chloromethyl-1H-indole-2-carboxylates: Replacement of sulfonic acid functionality by chlorine

Béla Pete, L. Tőke

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Valuable new synthetic intermediates, 5-chloromethyl-1H-indole-2-carboxylates, were prepared by the elimination of SO2 from 2-ethoxycarbonyl-1H-indole-5-methanesulfonic acids, which are easily accessible by Fischer-type indolization.

Original languageEnglish
Pages (from-to)3373-3375
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number19
DOIs
Publication statusPublished - May 7 2001

Fingerprint

Sulfonic Acids
Chlorine
Derivatives
indole
methanesulfonic acid
indole-2-carboxylate

Keywords

  • 3,5-disubstituted 2-carboxyindoles
  • Desulfination
  • Fischer synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

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abstract = "Valuable new synthetic intermediates, 5-chloromethyl-1H-indole-2-carboxylates, were prepared by the elimination of SO2 from 2-ethoxycarbonyl-1H-indole-5-methanesulfonic acids, which are easily accessible by Fischer-type indolization.",
keywords = "3,5-disubstituted 2-carboxyindoles, Desulfination, Fischer synthesis",
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T2 - A facile synthesis of 5-chloromethyl-1H-indole-2-carboxylates: Replacement of sulfonic acid functionality by chlorine

AU - Pete, Béla

AU - Tőke, L.

PY - 2001/5/7

Y1 - 2001/5/7

N2 - Valuable new synthetic intermediates, 5-chloromethyl-1H-indole-2-carboxylates, were prepared by the elimination of SO2 from 2-ethoxycarbonyl-1H-indole-5-methanesulfonic acids, which are easily accessible by Fischer-type indolization.

AB - Valuable new synthetic intermediates, 5-chloromethyl-1H-indole-2-carboxylates, were prepared by the elimination of SO2 from 2-ethoxycarbonyl-1H-indole-5-methanesulfonic acids, which are easily accessible by Fischer-type indolization.

KW - 3,5-disubstituted 2-carboxyindoles

KW - Desulfination

KW - Fischer synthesis

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JO - Tetrahedron Letters

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