Synthesis of 5'-deoxy-5'-[18F]fluoro-adenosine by radiofluorination of 5'-deoxy-5'-haloadenosine derivatives

Sz Lehel, G. Horvath, I. Boros, P. Mikecz, T. Márián, L. Trón

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

5'-Deoxy-5'-[18F]fluoro-adenosine was synthesised by nucleophilic radiofluorination reactions of 5'-deoxy-5'-haloadenosines. The homogeneous isotope exchange in 5'-deoxy-5'-fluoro-adenosine was also investigated. The conversion of these reactions was found to be rather low and depends on the strength of the halogen-carbon bond: 0.248% for chloride-, 0.488% for bromide- and 1.070% for iodide-derivative; there was no reaction observed in the case of fluoro-compound.

Original languageEnglish
Pages (from-to)399-401
Number of pages3
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume245
Issue number2
DOIs
Publication statusPublished - 2000

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Adenosine
Isotopes
Conversion Disorder
Derivatives
Halogens
Carbon
Iodides
Bromides
Chlorides

ASJC Scopus subject areas

  • Analytical Chemistry
  • Inorganic Chemistry
  • Nuclear Energy and Engineering

Cite this

Synthesis of 5'-deoxy-5'-[18F]fluoro-adenosine by radiofluorination of 5'-deoxy-5'-haloadenosine derivatives. / Lehel, Sz; Horvath, G.; Boros, I.; Mikecz, P.; Márián, T.; Trón, L.

In: Journal of Radioanalytical and Nuclear Chemistry, Vol. 245, No. 2, 2000, p. 399-401.

Research output: Contribution to journalArticle

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AU - Mikecz, P.

AU - Márián, T.

AU - Trón, L.

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