Synthesis of 4,5-dihydro-1,4-benzothiazepine derivatives via ring expansion

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Basic treatment in methanol of a chloro-β-lactam fused with dihydrobenzothiazine led to the corresponding 1,4-benzothiazepine derivative via a new ring expansion. The structure of the product, deduced from IR and 1H NMR data, was confirmed by X-ray measurements.

Original languageEnglish
Pages (from-to)5077-5078
Number of pages2
JournalTetrahedron Letters
Issue number50
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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